I've changed a little bit. the acrylic is tough for cnc spindle but it could be easily cut by laser. I've use 300mm/min feed rate and 4000rpms spindle. But the quality of the edges of the acrylic after cut is totally disaster.
Cutting acrylic on a CNC is a piece of cake. When dealing with plastics, heat is your enemy. To help with that, you want to remove chips. An o-flute is the only endmill I use in plastics of any kind (except HDPE). I have a router. I believe I had it set to 20k rpm, 1000mm/min feed, 300mm/min plunge, and a 2mm max DOC. Holding the work piece starts to become a struggle after this point for me.